Main ingredient: Doxycycline hydrochloride

Properties: Ichi chigadzirwa chine chiedza chegirini.

Pharmacological chiito:

Pharmacodynamics:Ichi chigadzirwa ndeye tetracycline yakakura-spectrum antibiotic ine yakakura-spectrum antibacterial effect. Mabhakitiriya anonzwa anosanganisira mabhakitiriya eGram-positive akadai sepneumococcus, streptococcus, mamwe staphylococcus, anthrax, tetanus, corynebacterium uye mamwe mabhakitiriya eGram-negative akadai seEscherichia coli, Pasteurella, Salmonella, Brucella uye Haemophilus, Klebsiterella uye meliophilus. Inogonawo kudzivisa Rickettsia, mycoplasma uye spirochaeta kune imwe nhanho.

Pharmacokinetics:Kukurumidza kutorwa, kupesvedzera kushoma nechikafu, yakakwirira bioavailability. Iko kusimba kweropa kunoshanda kunochengetedzwa kwenguva yakareba, iyo tishu permeability yakasimba, kugovera kwakafara, uye zviri nyore kupinda musero. Iyo yakatsiga-inooneka vhoriyamu yekugovera mumbwa ndeye 1.5L/kg. High protein binding rate yembwa 75% kusvika 86%. Chikamu chisina kushandiswa ne chelation mumatumbo, 75% yedosi yembwa inobviswa nenzira iyi. Renal excretion inenge 25% chete, biliary excretion iri pasi pe5%. Hafu yehupenyu hwembwa inenge maawa gumi kusvika gumi nemaviri.

Kudyidzana kwezvinodhaka:

(1) Kana yakatorwa nesodium bicarbonate, inogona kuwedzera pH kukosha mudumbu uye kuderedza kunyura uye kuita kwechigadzirwa ichi.

(2) Ichi chigadzirwa chinogona kuumba macomplexes ane divalent uye trivalent cations, nezvimwewo, saka kana iwo akatorwa aine calcium, magnesium, aluminium uye mamwe maantacids, ine iron-ine zvinodhaka kana mukaka uye zvimwe zvekudya, kutora kwavo kunoderera, zvichikonzera kuderedza kushandiswa kwezvinodhaka muropa.

(3) Kushandiswa kwakafanana neakasimba diuretics se furthiamide kunogona kuwedzera kukuvadzwa kwetsvo.

(4) Inogona kukanganisa bactericidal mhedzisiro yepenicillin panguva yekuberekesa bhakitiriya, inofanira kudzivirira kushandiswa kwakafanana.

Zviratidzo:

Utachiona hwehutachiona hwakanaka, mabhakitiriya asina kunaka uye mycoplasma. Zvirwere zvekufema (mycoplasma pneumonia, chlamydia pneumonia, feline nasal bazi, feline calicivirus chirwere, canine distemper). Dermatosis, genitourinary system, gastrointestinal utachiona, nezvimwewo.

Kushandiswa uye dosage:

Doxycycline. Nokuda kwehutungamiri hwemukati: imwe yero, 5 ~ 10mg pa1kg yehuremu hwembwa nekatsi. Inoshandiswa kamwe chete pazuva kwemazuva 3-5. Kana sezvakataurwa nachiremba. Inokurudzirwa kutora mushure mekudya uye kunwa mvura yakawanda mushure mekutonga kwemuromo.

Yambiro:

(1) Hazvikurudzirwe kune imbwa uye katsi pasi pemavhiki matatu vasati vasununguka, lactation, uye 1 mwedzi wezera.

(2) Shandisa nekuchenjerera mumbwa nekatsi dzine chiropa chakakomba uye kusagadzikana kwetsvo.

(3) Kana iwe uchida kutora calcium supplements, iron supplements, mavitamini, antacids, sodium bicarbonate, nezvimwewo panguva imwe chete, tapota zvishoma 2h interval.

(4) Inorambidzwa kushandisa ne diuretics uye penicillin.

(5) Yakasanganiswa ne phenobarbital uye anticoagulant ichakanganisa basa reumwe neumwe.

Adverse reaction:

(1) Muimbwa nekatsi, zvinowanzoitika zvakashata zvinokonzerwa nemuromo doxycycline kurutsa, manyoka, uye kuderera kwechido. Kuti uderedze kuita kwakashata, hapana kuderera kukuru kwekutorwa kwezvinodhaka kwakaonekwa kana kutorwa nechikafu.

(2) 40% yembwa dzakarapwa dzaive nekuwedzera kwechiropa-chekuita-ane enzymes (alanine aminotransferase, basic conglutinase). Kukosha kwekiriniki kwekuwedzera kwechiropa basa rine chekuita nema enzymes hazvina kujeka.

(3) Oral doxycycline inogona kukonzera esophageal stenosis mumakati, akadai semapiritsi emuromo, inofanira kutorwa nemvura inenge 6ml, kwete yakaoma.

(4) Kurapa ne tetracycline (kunyanya kwenguva refu) kunogona kutungamirira kukukura kwebhakitiriya isinganzwisisi kana fungi (chirwere chetachiona kaviri).

Chinangwa: Chete katsi nembwa.

Tsanangudzo: 200mg/ piritsi