Imidacloprid uye Moxidectin Spot-on Solutions (yeImbwa)

【Main Ingredient】

Imidacloprid, Moxidectin

【Chitarisiko】

Yellow kusvika kubrown mvura yeyero.

【PHarmacologic chiito】

Antiparasite mushonga.

Pharmacodynamics:Imidacloprid chizvarwa chitsva che chlorinated nicotine insecticides. Iine hukama hwepamusoro hwe postsynaptic nicotinic acetylcholine receptors mukati mehutano hwehutano hwezvipembenene, uye inogona kudzivisa basa reacetylcholine, zvichiita kuti parasite iparare uye rufu. Inoshanda kurwisa nhata dzevakuru uye nhata diki pamatanho akasiyana, uye zvakare ine kiling mhedzisiro padiki nhata munzvimbo. Iyo nzira yekuita yemoxidectin yakafanana neyeabamectin uye ivermectin, uye ine yakanaka kiling mhedzisiro yemukati nekunze tupukanana, kunyanya nematodes uye arthropods. Kuburitswa kwebutyric acid (GABA) kunowedzera simba rayo rekusunga kune postsynaptic receptor, uye chiteshi chechloride chinovhura. Moxidectin inewo kusarudza uye kushamwaridzana kwepamusoro kweiyo glutamate-mediated chloride ion channels, nokudaro kupindira neuromuscular signal transmission, kuzorora uye kuoma mitezo, zvichiita kuti kufa kwezvipembenene. Inhibitory interneurons uye excitatory motor neurons mu nematodes ndidzo nzvimbo dzayo dzekuita, nepo mu arthropods iri neuromuscular junction. Iko kusanganiswa kwezviviri kune synergistic effect.

Pharmacokinetics:Mushure mekutonga kwekutanga, imidacloprid yakakurumidza kugoverwa kumuviri wembwa pazuva rimwe chete, uye yakaramba iri pamusoro pemuviri panguva yekutonga kwemazuva 4-9 mushure mekutonga, iyo plasma yemoxidectin mumbwa inosvika pakakwirira, uye inoparadzirwa mumuviri wose mukati memwedzi mumwe uye inogadziriswa zvishoma nezvishoma uye inobudiswa.

【Zviratidzo】
Nekudzivirira uye kurapwa kwemukati uye kunze kwehutachiona hwehutachiona mumbwa. Kudzivirira uye kurapwa kwenhata infestations (Ctenocephalic canis), kurapwa kwezvipembenene (Catonicus canis), kurapwa kwenzeve mite infestations (ltchy otica), canine sarcoids (Scabies mites), uye demodicosis (Demodex canis), kurapwa kweAngiostrongylus uye gastrointestinal nematode zvirwere (vakuru, immature aduts uye L4makonye eToxocara canis, Ancylostoma canis, and Ancylocephalus larvae;vakuru veToxocara lionis uye Trichocephala vixensis). Uye inogona kushandiswa se adjuvant kurapwa kweallergic dermatitis inokonzerwa nenhata.

【Kushandiswa uye chipimo chemushonga】
Kushandiswa kwekunze, donhedza chigadzirwa ichi paganda kubva kumashure kwembwa pakati pemapendekete maviri kusvika kumagaro, uye ugokamure kuita 3-4 nzvimbo. Chiyero chimwe, chembwa, pa1kg yehuremu hwemuviri, 10mg yemidacloprid uye 2.5mg yemoxidectin, yakaenzana ne0.1ml yechigadzirwa ichi. Munguva yeprophylaxis ortreatment, zvinokurudzirwa kutungamirira kamwe chete pamwedzi. Dzivirirai imbwa kunanzva.

【Side effect】

(1) Muzviitiko zvega, chigadzirwa ichi chinogona kukonzera kusawirirana kwenzvimbo, zvichikonzera kukwenya kwenguva pfupi, kunamatira kwebvudzi, erythema kana kurutsa. Zviratidzo izvi zvinopera pasina kurapwa.

(2) Mushure mekutonga, kana mhuka ichinanzva nzvimbo yekutonga, zviratidzo zvenguva pfupi zvetsinga zvinogona kuonekwa nguva nenguva, zvakadai sekufara, kudengenyeka, zviratidzo zvemaziso (vana vakareruka, pupillary reflexes, uye nystagmus), kufema kusina kujairika, salivation, uye Zviratidzo zvakadai sekurutsa. ; pano neapo kuchinja kwemaitiro kwekanguva sekusada kuita maekisesaizi, kufara, uye kurasikirwa nechido kunoitika.

【Zvekungwaririra】

(1) Usashandise vana vari pasi pemavhiki manomwe ezera. Imbwa dzine allergic kune chigadzirwa ichi haifaniri kuishandisa. Imbwa dzine pamuviri uye dzinoyamwisa dzinofanira kutevera mazano ezvechiremba asati ashandisa.

(2) Imbwa dziri pasi pe1kg dzinofanira kutevedzera kuraira kwemhuka kana uchishandisa chigadzirwa ichi.

(3)Chigadzirwa ichi chine moxidectin(macrocyclic lactone), saka kana uchishandisa chigadzirwa ichi pamacollies, imbwa dzechirungu dzechirungu dzemakwai nemhando dzinoenderana, kutarisisa kunofanirwa kubhadharwa kudzivirira imbwa idzi kuti dzisananzva izvi.chigadzirwa nemuromo.

(4)Imbwa dzinorwara nembwa dzine muviri usina kusimba dzinofanira kutevedzera zano revarapi vemhuka kana dzichiishandisa.

(5) Ichi chigadzirwa hachifanirwe kushandiswa pamakatsi.

(6)Panguva yekushandiswa kwechigadzirwa ichi, usabvumira mushonga uri muchubhu yezvinodhaka kuti ubatane nemaziso nemuromo wemhuka inotungamirirwa kana dzimwe mhuka.Dzivisa mhuka dzinenge dzapererwa nemushonga kuti dzisananzvane. Usagunzva kana kucheka bvudzi kusvikira mushonga waoma.

(7) Dzimwe nguva 1 kana 2 kuratidzwa kwembwa kumvura panguva yekutonga hakuzokanganisa zvakanyanya kushanda kwemushonga. Nekudaro, kugara uchishandiswa kwe shampoo pakugeza kana kunyudzwa mumvura nembwa kunogona kukanganisa kushanda kwemushonga.

(8) Chengetedza vana kuti vasaonane nechigadzirwa ichi.

(9)Usachengeta kupfuura makumi matatu℃,uye usashandise kupfuura iyo label zuva rekupera.

(10) Vanhu vasingawirirani nechigadzirwa ichi havafanire kuchipa.

(11) Paunenge uchipa mushonga, mushandisi anofanira kudzivirira kubata neganda, maziso nemuromo wechigadzirwa ichi, uye usadye, kunwa kana kuputa; mushure mekutonga, maoko anofanira kushambidzwa. Kana ikasawa paganda netsaona, geza nesipo nemvura nekukurumidza; kana ikasawarira mumaziso, igeze nemvura nekukasika.

(12) Parizvino, hapana mushonga chaiwo wekununura wechigadzirwa ichi; kana ikamedzwa nekukanganisa, marasha akaiswa mumuromo anogona kubatsira kubvisa.

13 Isati yaoma saiti yekutonga, dzivirira zvinhu izvi kuti zvisabate saiti yekutonga

(14) Usarege chigadzirwa ichi kupinda pamusoro pemvura.

(15)Mishonga isingashandiswe uye zvinhu zvekurongedza zvinofanirwa kuraswa nenzira isingakuvadzi zvichienderana nezvinodiwa munharaunda.

【Withdrawal  period】Hapana

【Tsanangudzo】

(1)0.4ml:Imidacloprid 40mg +Moxidectin 10mg

(2)1.0ml:Imidacloprid 100mg+Moxidectin 25mg

(3)2.5ml:Imidacloprid 250mg +Moxidectin 62.5mg

(4)4.0ml:Imidacloprid 400mg+Moxidectin 100mg

 【Storage】

Yakavharwa, yakachengetwa pakamuri tembiricha.

【Sherufu hupenyu】

3 years