Demenidazole, sechizvarwa chekutanga che antigenic insect drugs, mutengo wayo wakaderera unoita kuti ishandiswe zvakanyanya mukurapa kwezvipfuyo kuchipatara kuongororwa uye kurapwa.Nekudaro, nekushandiswa kwakakura kwemhando iyi yemishonga uye chizvarwa chekare uye chekare chenitroimidazoles, dambudziko rekupokana nemishonga mukushandisa rinozonyanya kuoneka.

01Anti anaerobic effect

Nekudaro, kushandiswa kwayo kwakakura mukugadzirwa kwehuku kunonyanya kuratidzwa mune anti anaerobic bacteria.Mumakumi emakore apfuura, yakashandiswa zvakanyanya mukurapa huku necrotic enteritis, enterotoxic syndrome uye kuzvimba kwe oviduct.Nekudaro, kunzwira kwayo kune anaerobes kuri kuramba kuchiwedzera.Chikonzero ndechekuti: kwenguva yakareba munguva yakapfuura, kushungurudzwa uye kushandiswa kusingaenzaniswi kwacho kwakakonzera kuwedzera kupikisa kwemhando dzakasiyana-siyana dzeanaerobic mabhakitiriya kune iyo gore negore, uye kutarisa kuchiri kushanda.Kuti vadzivise tsika iyi yakaipa yebudiriro, dhipatimendi rakakodzera remishonga yezvipfuyo rakairambidza zvakajeka makore anopfuura gumi apfuura: inogona kushandiswa chete mukupfuya nekugadzirwa kwemhuka dzinoshandiswa zvakanyanya kudya, uye inogona kushandiswa chete kupfuya zvipfuyo nehuku, mhuka dzinovaraidza uye zvimwe zvisiri zvekudya zvakakosha.

02Sainzi uye kuenderana kunonzwisisika

Muchikamu chekuenderana kwekushandiswa zvisina musoro kwedemenidazole, chekutanga, haifanirwe kushandiswa pamwe chete nemethamphenicol, florfenicol uye mamwe amido alcohol antibiotics, nekuti demenidazole inogona kukonzera mwongo dysplasia muzvipfuwo uye huku, uye kana ikashandiswa pamwe chete nezviri pamusoro apa. amido doro remishonga inorwisa mabhakitiriya, inozowedzera njodzi yekuipa kwakashata muhurongwa hweropa.

Chechipiri, haifaniri kushandiswa ne ethanol kana kugadzirira ine yakawanda ye ethanol, nokuti kusanganiswa kwezviviri kuchaita kuti disulfiram iite, uye mhuka dzinorwara dzinogona kuva nezvimwe zviratidzo zvehutano hwehutano.Mukuwedzera, kushandiswa kwedoro kana zvinodhaka zvine doro rakawanda kunofanira kuderedzwa zvakanyanya sezvinobvira mukati memazuva 7-10 mushure mekubviswa kwezvinodhaka.

Chechitatu, kunyanya kumhizha yezvokurapa kwemhuka, kutanga, haifaniri kusanganiswa nemishonga inosuppressive, kana zvisina kudaro, demenidazole inogona kudzivisa kuitika kwe mycophenolate mofetil pamuviri.Chechipiri, haigone kushandiswa nemuromo anticoagulants, iyo inosimudzira iyo anticoagulant mhedzisiro yemuromo anticoagulants yakadai sewarfarin, kuitira kuti mhuka dzinovaraidza dziwedzere njodzi yekubuda ropa.

Chekupedzisira, izvi zvinonyanya muindasitiri yekurapa kwemhuka.Kutanga, haigone kusanganiswa nechiropa chinodhaka enzyme inhibitors.Semuenzaniso, chiropa chinodhaka enzyme inhibitors senge cimetidine chinogona kutadzisa metabolism ye metronidazole.Kana yakabatanidzwa, zvinodikanwa kuona kuwanda kwemishonga yeropa uye kugadzirisa iyo dose pakarepo.Chechipiri ndechekuti haigone kushandiswa nehepatic drug enzyme inducers.Kana yakabatanidzwa nehepatic drug enzyme inducers yakadai se phenytoin, metabolism ye demenidazole ichakurumidza kukurumidza uye kuiswa kweplasma kuchaderedzwa;Iyo metabolism ye phenytoin uye mamwe ehepatic drug enzyme inducers yakadzikiswa uye huwandu hweplasma hwakawedzerwa.

03Kugadzirira kunobata maitiro ekurapa

Nekuti demenidazole pachayo inonyungudika zvishoma mumvura uye inorwisa mabhakitiriya inoenderana nenguva, kukanganisa kwayo kwemishonga uye hunhu hwepharmacodynamic hunoratidza kuti "kugadzirira kunoratidza kushanda".Isu tinowanzoona muuswa-midzi mayuniti kuti solubility ye dimenidazole premix chigadzirwa inonyanya kuderera.Mushure mekuwedzera huwandu hwemvura uye kusanganisa zvakakwana, kune "nhamba yakawanda yezvinhu zvisinganyunguriki" mumuenzaniso wejecha rakanaka.Izvi handizvo chaizvo zvemugadziri "sophistry" yekudaidza dambudziko remhando yemvura, kana kutaura zvenhema kuti izvo zvisinganyunguduke zvinhu zvinobatsira uye zvimwe zvisiri zvemishonga.

Zvese zvakadai zvakasanganiswa zvigadzirwa zve dimenidazole, kuwedzera kune zvakachipa uye zvakachipa, zvakabatana "hapana mhedzisiro".

Naizvozvo, ruzhinji rwevarimi veuswa nevashandisi vemishonga yezvipfuyo vanofanirwa kutarisisa kune "yemhando yepamusoro" zvigadzirwa zvine zvakakwana zvinodhaka zvemukati uye yakanaka solubility pakusarudza dimenidazole premix zvigadzirwa zvekurapa zvirwere zveanaerobic mugumbo rekudya kana hurongwa hwekubereka.Pamusoro pekusarudzwa kwemishonga, danho rinonyanya kukosha nderekuti: zvinoenderana nechinangwa chekuwedzera kuramba zvinodhaka, isu tinofanirwa kuita basa rakanaka mumubatanidzwa, synergy uye kushandiswa kwekubatana kweanti drug resistance, kuitira kuti tiwedzere uye kuratidza "kubudirira" kwekurapa zvinodhaka.